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KMID : 0378019840270050113
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New Medical Journal
1984 Volume.27 No. 5 p.113 ~ p.118
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The Clinical Trial of Naloxone, a specific narcotic antagonist on Various Patients with Coma
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안병민/Ahn, Byung Min
김관형/최상덕/정진우/유재영/박두호/김부성/Kim, Kwan Hyung/Choi, Sang Duck/Jeong, Jin Wu/Yoo, Jae Young/Park, Doo Ho/Kim, Boo Sung
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Abstract
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Naloxone (N-allylnoroxymorphone) is a specific, potent narcotic antagonist which antagonizes the effect of the ß-endorphin and elevates the plasma dopamine levels in various stress, hypovolemic, cardiogenic or septic shock state.
We evaluate the clinical effectiveness of naloxone in 14 patients with CO intoxication, 15 with sedative over dosage and 20 with cerebral stroke patients.
The results were as follows;
1) In case of CO intoxication, 9 out of 14 patients (64.3%) showed moderate to marked clinical improvements.
2) All 15 patients with sedative overdosage recovered consciousness level and increased respiratory rates, pupil size and systolic blood pressure just after intravenous injection of 0.4mg of naloxone.
3) Five out of six patients (83.3%) with transient cerebral ischemic attack and 5 out of 8 patients (12.5%) with cerebral hemorrhage revealed moderate to marked improvement in neurological deficits including mental state, but little or no effect in patients with cerebral infarction.
4) The effect of naloxone began to start three to five minutes after the intravenous injection without remarkable toxicity, but wore off gradually, and careful observation of the patient was necessary.
5) In conclusion, our clinical data suggested that naloxone is effective in acute stage of CO intoxication, sedative overdosage and in cerebral stroke, however, long-term effect of this drug should be more evaluated.
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